Project Description

E. Alison Holman
PhD, APRN, FNP, FAAN

Director of PhD Program

Associate Professor

Key Areas of Focus

  • Key Area of Focus 2: Community Health
  • Key Area of Focus 6: Health Disparities and Diversity

Areas of Expertise

  • Health consequences of individual/community trauma
  • Acute & post-traumatic stress
  • Genetic vulnerability to stress-related cardiovascular disease
  • Inter-generational transmission of trauma & health
  • Resilience
  • Media exposure to collective trauma

Research Abstract

My research focuses on understanding the early post-event predictors of comorbid trauma-related mental and physical health problems. I seek to identify predictors of, contributions of, and interactions between acute responses to trauma (biological, cognitive, emotional, social, environmental, behavioral) that increase vulnerability to trauma-related health problems, especially cardiovascular disease. Toward this end, I examine gene-environment interactions and the roles of several biological systems in acute/post-traumatic stress response: renin-angiotensin-aldosterone, endocannabinoid, and oxytocin systems as well as hypothalamic-pituitary-adrenal axis response. The ultimate goal is to identify targets for early interventions to prevent trauma-related morbidity and mortality.

Additional info on the UCI Faculty Profile System